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Raffaele Spano
Research center
About

Dr. Raffaele Spanò has been a Technician in the Nanotechnology for Precision Medicine research line at the Istituto Italiano di Tecnologia since July 2019.

He focuses on developing Polymeric Microparticles loaded with thrombolytic drugs, such as Tissue-Type Plasminogen Activator, for therapeutic applications in vascular diseases.

He holds a Ph.D. in Tissue Engineering and Regenerative Medicine from the Università Degli Studi di Genova.

During his Ph.D., he developed a Human Platelet-Rich Plasma-based additive for cell culture and skin dressings to enhance wound healing, detailed in his thesis, "Platelet derivatives: from the Laboratory Bench to the Bedside."

Dr. Spanò also earned an MSc Degree in Applied Science, Medical, and Pharmaceutical Biotechnology from the Università Degli Studi di Genova, where his thesis, "Alteration of bone turnover and growth plate in transgenic mice overexpressing Lipocalin-2 in bone," focused on significant discoveries.

Early in his career, he contributed to groundbreaking bone and cartilage regeneration research using stem cells and blood derivatives.

Education

Title: Ph.D. in Tissue Engineering and Regenerative Medicine
Institute: Università degli Studi di Genova
Location: Genova
Country: Italy
From: 2013 To: 2016

Title: Master Degree in Applied Science, Medical and Pharmaceutical Biotechnology
Institute: Università degli Studi di Genova
Location: Genova
Country: Italy
From: 2006 To: 2011

All Publications
2026
Murgia D., Pandey A., Spano R., Martins Estevao B., Palomba R., Avancini G., Gupta T., Lopez Estevez A.M., Goodman S.B., Bhutani N., Decuzzi P.
Liposomal Delivery of L-2-Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis
Advanced NanoBiomed Research
Article Journal
2026
Guerriero I., Pesce C., Spano R., Sganga S., Tirelli N., Palange A.L., Di Mascolo D., Decuzzi P.
Programming Degradation and Drug Release Through Micropatterning of PLGA Films
ACS Applied Materials and Interfaces, vol. 18, (no. 20), pp. 28464-28478
Article Journal
2025
Spano R., Portioli C., Geroski T., Felici A., Palange A.L., Gawne P.J., Mamberti S., Avancini G., Palomba R., Bonnard T., Moore T.L., Del Sette M., Filipovic N., Vivien D., Decuzzi P.
Enhancing Thrombolysis Safety in Post-Acute Ischemic Stroke with Tissue Plasminogen Activator-Associated Microparticles
ACS Nano, vol. 19, (no. 25), pp. 22882-22899
Article Journal
2024
Portioli C., Spanò R., Murgia D., Mamberti S., Estevão B.M., Cancedda L., Decuzzi P.
Anti-inflammatory Microparticles to tackle Neurodevelopmental Disorders
Controlled Release Society
Conference Paper Conference
2024
Romaldini A., Spano R., Veronesi M., Grimaldi B., Bandiera T., Sabella S.
Human Multi-Lineage Liver Organoid Model Reveals Impairment of CYP3A4 Expression upon Repeated Exposure to Graphene Oxide
Cells, vol. 13, (no. 18)
Article Journal